Industry Insight
Discovery Technology
Analytical Laboratory Technology
Delivery Systems
Ingredients, Formulation and Finishing
View our other publications with free access to extensive archives


 10th February 2012 Hielscher Ultrasonics

UP400S Ė Powerful Sonication of Larger Samples

400 Watts ultrasonic power - The UP400S (400W, 24kHz) is a powerful and reliable ultrasonic device for the sonication of larger samples in the lab. Typical application include: Homogenization, deagglomeration, lysis and cell disintegration, protein extraction and the emulsification of liquids.

The ultrasonic processor UP400S (400 watts, 24kHz) is Hielscherís most powerful laboratory device. With sonotrodes of a diameter range from 3 to 40mm the device is suited for the sonication of sample volumes from 5 to 4000ml. In flow approx. 10 to 50 liters per hour can be sonicated. For the preparation of samples the UP400S is mainly used for bigger volumes.

The standmounted device combines generator (power supply) and transducer (converter) in a single housing. This saves desktop space and weight. The only plug to be connected is the main power plug, that fits into standard 115V~ or 230V~ outlets. The operation of the ultrasonic homogenizers is very simple. The devices are tuned to the optimal resonant frequency automatically, so there is no need for manual adjustments. The ultrasonic amplitude is adjustable from 20 through 100%. Alternatively to the continuous operation a cycle of intense sonication bursts can be adjusted, e.g. for the sonication of heat-sensitive tissue.

It is suited for the development of ultrasonic applications in the laboratory but also in the bench top optimization as well as for the production of small quantities. For production quantities a PC-control or a remote interface to a central control of the userís facility is recommended in order to raise the process safety and reproducibility. The PC-control improves the reproducibilty when following specific sonication protocols. With special flow cells and flange connections liquids can also be sonicated at elevated temperatures and pressures.

Hielscher ultrasonic laboratory devices can run continuously - 24hrs/7days, if needed. By using the laboratory devices in combination with flow cell reactors, you can process larger sample volumes. In this case, the liquid is pumped into the reactor made of glass or stainless steel. With an UP400S ultrasonic device approx. 10 to 50 liters per hour can be processed. There it is exposed to defined intense sonication before it reaches the exit of the reactor cell. In order to cool heat-sensitive material during sonication, the flow cells are jacketed to improve heat dissipation. High power generates the intensive cavitation required, but this results in unwanted noise. For operating the UP400S we recommend to use the sound protection box to provide a more convenient environment.

Direct link:

Hielscher Ultrasonics Warthestr. 21 14513 Teltow, Germany Tel.: +49 3328 437 3 Fax: +49 3328 437 444 Email: Web:


Advair,Flovent,VentolinSymbicort,Serevent,FlonaseAstelin Rhinocort
IPT © 2021 Innovations in Pharmaceutical Technology | Terms and Conditions | | UK Contacts |
Providing a platform of communication on new ideas, developments and innovations | UK Tel No. +44 20 77243456 | Back to top of page |