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Circular Argument

Although macrocycles appear to behave like biologics in binding with high affinity to challenging protein targets, they retain the pharmaceutical properties of small molecules presenting vast potential for future drug discovery, explains Nicholas K Terrett at Ensemble Therapeutics.

Nicholas K Terrett, Ensemble Therapeutics (December 2014)

Keywords: Protein-protein interactions, Large-molecule biologics, Oral bioavailability, Synthetic variation, Hydrogen-bonding groups

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