Circular Argument

Although macrocycles appear to behave like biologics in binding with high affinity to challenging protein targets, they retain the pharmaceutical properties of small molecules – presenting vast potential for future drug discovery, explains Nicholas K Terrett at Ensemble Therapeutics.

Nicholas K Terrett, Ensemble Therapeutics (December 2014)

Keywords: Protein-protein interactions, Large-molecule biologics, Oral bioavailability, Synthetic variation, Hydrogen-bonding groups

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