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Allosteric Modulation: a Novel Approach To Drug Discovery

Allosteric modulators of GPCRs have emerged as a novel and highly desirable class of compounds, offering a number of distinct advantages over conventional competitive compounds; their increased selectivity, self-limiting activity and structural novelty should translate into promising new drugs for a wide range of diseases

Mark Epping-Jordan, Emmanuel Le Poul and Jean-Philippe Rocher (January 2008)

Keywords: Allosteric modulation, GPCRs as drugs, superior receptor subtype selectivity

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