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Fragment-Based Drug Design

By careful selection and experimental design, fragments can provide very useful starting points for medicinal chemistry-driven programmes, leading to tailor-made, selective molecules with highly favourable physico-chemical and ADMET properties

David Bailey, Susan Boydand Paul England at IOTA Pharmaceuticals Ltd, and Iwan de Esch at IOTA and the Department of Medicinal Chemistry, Vrije Universiteit, Amsterdam (May 2008)

Keywords: The FBDD Approach, Developments in structural biology and high-sensitivity screening, Surface Plasmon RESONANCE (SPR)

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