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Targeting HIV-1 Reverse Transcriptase:a Coat with Many Pockets

The absolute dependence of HIV-1 Reverse Transcriptase and thus HIV replication on ribonuclease H activity suggests that small molecules targeting this function offer potential as anti-AIDS therapies, especially if they can be shown to potentiate the activity of those drug combinations currently in use.

By Suhman Chung, Jason W Rausch and Stuart FJ Le Grice at the US National Cancer Institute (December 2009)

Keywords: HIV-1, Reverse Transcriptase, Chung, Rausch, Le Grice, NCI, retroviral ribonuclease, RNase, inhibitors,

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