Spring 2023
6. Approaches to Advance Viral Vector Development and Characterisation for Gene Therapy Applications – AJourney Through Vector Optimisation
How is rAAV vectorology being optimised and why is its development important?
10. The Challenges and Technological Opportunities in Oligonucleotide Therapeutics
How are nucleic acid sequences being analysed by mass spectrometry and how can the data be automatically processed?
18. AI in the Drug Discovery Industry
IPT talks to Tamsin Mansley of Optibrium about AI’s past and future involvement in drug discovery
20. Coding of Cell Identity
How are novel technologies helping researchers improve on non-human cells in drug discovery?
23. The Big Debate: The Future of Life Sciences’ Regulation and Processes Will Be Data-Driven – But Who Will Steer That Future?
Whose responsibility should it be to look after the quality and consistency of data, and how will they achieve this?
26. Accelerating Life Sciences Research and Delivery with Knowledge Graphs
Two studies demonstrate how knowledge graphs are improving data handling in drug discovery
30. Technological and Scientific Advances Bring New Hope for Therapeutic Cancer Vaccines
Cancer vaccines are becoming a reality through advances in immunotherapy and other areas
33. Next-Generation Enteric Capsule Innovation: How Next-Generation Capsule Technology is Helping API Reach Deeper Into the Small Intestine
Developments in material science and manufacturing innovation are creating a purpose-built capsules for enteric drug delivery
36. Esomeprazole Pellet Production for MUPS Applications – High-Precision Fluid Bed Coating
Fluid bed processors are utilising air flow bed technology in the development of pellet coating
38. Making Inhaled Therapies Fit for the Future: Improving the Sustainability of Pressurised Metered Dose Inhalers
Formulation changes are helping to make pMDIs more sustainable
41. How Flexible Containment Is Helping Manufacturers Meet Demand for Highly Potent Drugs
Why are manufacturers choosing flexible containment over traditional rigid isolators?
43. Next-Level Digitalisation: Smart Pharma Production Gets Even Smarter
How can companies improve lab digitalisation to aid growth?
EXECUTIVE DIRECTOR
PMGroup Worldwide Ltd
Karl Equi
GROUP MANAGING EDITOR
Iona Everson
DEPUTY EDITOR
George Barker
EDITORIAL AND PRODUCTION ASSISTANT
Charlie Blackie-Kelly
EDITORIAL ASSISTANTS
James Spargo
Betsy Goodfellow
SALES
Simon Caplan
DESIGN
Peter May
FRONT COVER
RGtimeline – Shutterstock.com
DIGITAL EDITION
by IPT Online
www.iptonline.com
CONTACT US
Tel: +44 (0)20 7724 3456
Fax: +44 (0)20 7403 7747
PRINTING
Hardings Print Solutions
www.hps-ltd.org.uk
SUBSCRIPTIONS AND DATA
Curwood CMS Ltd
Unit 9 Barns & Stables, Timworth Green,
IP31 1HS
c-cms.com
Tel: 01580 883841
Email: enquiries@c-cms.com
www.iptonline.com
Innovations in Pharmaceutical Technology (ISSN: 1471-7204, USPS No: 025082) is published four times a year – March, June, September, and December – by Samedan Ltd.
The opinions and views expressed by the authors in this book are not necessarily those of the Editor the Publisher and, while every care has been taken in the preparation of the book, the Editor and the Publisher are not responsible for such opinions and views or for
any inaccuracies in the articles.
The Publisher is not responsible for any images supplied by contributors. While every care is taken with artwork supplied, the Publisher cannot be held responsible for any loss or damage incurred.
The entire content of this publication is protected by copyright. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form, by any means – electronic,
mechanical, photocopying, or otherwise – without the prior permission of the Publisher.
© 2023 Samedan Ltd
Pharmaceutical Publishers