Spring 2025

10 SPOTLIGHT

Multi-tip tooling: a guide What are some challenges with multi-tip tooling, and how can these be overcome?

13 Cell processing platforms in biologics therapeutics manufacturing

Julien Muzard at Entegris speaks to IPT about how innovations in downstream cell processing platforms will improve biologics therapeutics manufacturing, and the impact artificial intelligence will have on the sector.

17 SPOTLIGHT

CARBOGEN AMCIS: advancing pharmaceutical innovation – excellence in drug substance and drug product manufacturing

From molecule to market – accelerating drug development with precision and expertise.

23

mmc2025 (incorporating EMAG 2025): registration officially OPEN!

The Microscience Microscopy Congress is back for 2025!

26

Overcoming challenges in bispecific antibody production with mixed-mode chromatography and scalable purification solutions

Advances in mixed-mode chromatography and scalable purification strategies are optimising production, improving yield, purity and cost efficiency, while ensuring a seamless transition from research to commercial manufacturing.

30

At-line protein quantification: the quest for real-time data in biologic and viral vector development

Ruizhi Wang at Abselion talks to IPT about how non-optical sensor technologies are unlocking critical process data at the bench and bioreactor.

34

Exploring new dimensions with spatial multi-omics

The implementation of spatial technologies advances disease research, but challenges must be overcome before spatial multi-omics becomes broadly accessible.

38

The evolution and future of DNA sequencing

The evolution of DNA sequencing has brought advances in speed, cost and accessibility. However, what challenges are faced in throughput scale-up, and what promise does automation hold for transforming genomics and personalised medicine?

42 The use of genetic information in precision medicine

The pharma industry needs a way to ensure the right therapies are getting to the right patients, in a timely and cost effective way. How are advances in researchers’ understanding of genomics aiding not only precision medicine for rare diseases, but also for common health conditions?

45 Overcoming delivery barriers to unlock the full potential of RNA-based medicine

While RNA molecules have demonstrated promising results as therapeutics for difficult-to-treat disease indications, their current limitations in terms of delivery mean their full potential is not being realised. How can this be overcome?

48

AI-powered pharma in 2025: faster drugs, safer patients, smarter healthcare

Digital tools, such as artificial intelligence, are improving pharma drug discovery.

51

How technology will shape pharma in 2025

How will advancements in technology affect the pharma sector, from both commercial and R&D points of view?

54

Transforming pharmaceutical manufacturing with cyber-physical trust

James Kugler at EMD Digital/Merck speaks to IPT about how counterfeit drugs, regulatory pressures and supply chain vulnerabilities demand a greater level of transparency in pharmaceutical manufacturing. Cyber-physical trust platforms, which provide an immutable link between physical products and their digital twins, will set a new standard and revolutionise the industry.

6

Eds Desk

Spring has sprung – what does this mean for the pharmatech industry?

8

Product News

IPT highlights some of the most recent exciting advancements in pharmaceutical manufacturing.

62

Events

A collation of the top pharma events for spring 2025!

57

Automated labs: the future of drug R&D

IPT talks to David Fuller at Artificial Inc about how automated labs are revolutionising the pharma R&D space by connecting disparate systems, easing the burden of manual tasks on workers, and speeding up time-to-market with tools such as artificial intelligence.

60

Robotic automation in the pharma lab

IPT talks to Roya Amini-Naieni at Trilobio about robotic automation in pharma research, the different applications of softand hardware, and how the field is likely to develop over the next five years.

Inside Front Cover INTERPHEX

5 Future Labs Live

7 London Lab Live

12 AAPS National Biotechnology

Inside Back Cover London

25 Royal Microscopical Society

33 INTERPHEX Event Review

37 BIO-Europe Spring

41 Samedan

Conference

Biotechnology Show

Outside Back Cover Natoli